South Carolina improved to 6-1 with the win, matching its best start since starting the 2001 season 6-1.
Head coach Steve Spurrier improved to 4-0 in his career against North Carolina, winning those games by a combined score of 122-54.
Chris Smelley threw a career-high three touchdown passes, all in the first half. He hit the new high mark with a 12-yard pass to Jared Cook with 15 seconds remaining in the half.
The Gamecocks snagged multiple interceptions for the first time since plucking four out of the air against South Carolina State on Sept. 15. Both INTs came in the first half.
Emanuel Cook made two of the South Carolina's three interceptions, his first of the season. It was the first time a Gamecocks grabbed two interceptions since Fred Bennett snagged a pair against Alabama on Oct. 2, 2004.
The Gamecock defense held North Carolina scoreless in the first quarter, marking the first time an opponent has gone scoreless in the opening period since then-No. 11 Georgia failed to crack the scoreboard in the first 15 minutes.
Dion Lecorn's three-yard, first-quarter touchdown reception was the first of his career.
Kenny McKinley's 30-yard, first-quarter touchdown catch was his sixth of the season. No other Gamecock wide receiver has more than one.
The South Carolina offense put three touchdowns on the board in the first half for the first time this season.
The Gamecocks' 18-point halftime lead was their largest of the season.