The Hatters fall to 2-13 all-time against South Carolina; their last win over the Gamecocks came in 1975.
Stetson will face North Carolina State in an elimination game at 1 p.m. Sunday. The winner of that will play South Carolina at 7 p.m.
This was Stetson's fourth game of the year against a Southeastern Conference school; however, it was just their first loss. The Hatters swept Georgia in the opening series of the season.
The Hatters are 0-8 when allowing an opponent to score 10 or more runs.
1B Trey Blackman hit his first home run of the season in the 2nd inning.
RF Mitchel Brennan hit his third home run of the season and his second of the regional in the seventh inning. With that, he extends his hitting streak to eight games.
Brennan also set a season-high with three RBIs in the game.
DH Sean Emory had his third multi-hit game of the season, going 2-for-3 with a pair of singles and a run scored.
SOUTH CAROLINA NOTES
South Carolina improves to 47-14 on the season. They remain undefeated all-time at Carolina Stadium (5-0) in postseason games.
Carolina has now won 16 straight home postseason games, dating back to the 2002 Super Regional vs. Miami (Fla.).
The Gamecocks will play the winner of Sunday's NC State-Stetson game for the regional championship at 7 p.m. Sunday.
Carolina has won eight consecutive postseason games, dating back to their second game at the 2010 College World Series.
All nine Gamecock starters reached base at least once, and all nine scored at least one run in the game.
This was the 10th time this season South Carolina scored 10 or more runs. They are 10-0 in those contests. The last time was an 11-1 win over Charleston Southern on May 11.
Robert Beary's third-inning grand slam was the first of his career and his third home run of the year. Beary also tied a career-high with four RBI in the game.
Beary's slam was the second grand slam of the season for South Carolina; the other was hit by Christian Walker on April 5 vs. USC Upstate.
Steven Neff hit his fifth home run of the season to lead off the fifth inning; of his 14 hits this year, 10 have gone for extra bases.
Adrian Morales extended his hitting streak to seven games with a single in the second inning.
Colby Holmes earned a win for the third time in four starts. He has gone six innings or longer on six occasions this year; all six such starts have resulted in wins.